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- Weaning: Atopica (cyclosporine) and Prednisone
We started weaning Sadie from Prednisone, reducing by 25% each month. We are now at 15mg (from 40mg). While weaning off the Prednisone though, she (as many of you know….) began to have a bowel problem, which just got worse and worse and nothing helped it. Nothing. And as you all know, Sadie has had (Bells) Palsy on the right side of her face since June. So, we decided to keep the Prednisone at the 15mg (no more reductions for the time being) and start weaning off the Atopica. We are still on our first reduction, from 25mg twice a day, AM and PM, to 25mg in the AM and 10mg in the PM.
My question is: Do you think I should continue the reduction of Atopica completely (if she continues to do well, of course) and then start reducing the Prednisone again? Or do I get the Atopica down to 10mg a day, and then start reducing the Prednisone again?
I think it should be all the way off with the Atopica and then start reducing the Prednisone again, but wanted your input. My vet and I have discussed, and she basically thinks finish the Atopica and then go back to the Prednisone, but what did you all do? I do believe Sadie will be on a maintenance dose of Prednisone, possibly for her life – we’ll see.
As I write, she’s next to me chewing on a (USA) peanut butter rawhide. I keep taking the (chewed off) pieces away from her (garbage) – she glares (sweetly, but it’s a glare none the less).
Hugs, Linda (and Chewbacca Sadie)
Linda, I think I’m having the same problems – I suspect reducing the prednisone is causing some bowel issues. He’s been having funny poos now for a few months. They improve and then we’re back again.
I believe it’s one of the problems of prednisone, when it’s in the system for a while, it starts to take over the body’s different natural functions, so when we start to wean, problems start to arise. Joint issues, bowel problems – that weren’t there before. I’m going to ask the vet about it next time we go, but that, hopefully, wont be until the end of next month. Hopefully because if we go in any earlier, it means problems – so end of next month please Bingo. I’m really hoping that his little bot will get the hang of the lower dose and start to cope. Another reason for a slow reduction (I think).
My vet preferred to get Bingo off the prednisone and possibly leave him on some atopica, but just don’t know that we’ll be able to get him off the prednisone totally – vet still hopeful – I’m the unbelieving sour puss.
Bingo says “Linda, get your own chews – leave Sadie’s alone”.
Love Vally & Bingo
Linda another idea. Iv just stopped giving Bingo milk thistle. He still gets SAMe. One of the side effects of milk thustle is tummy trouble although supposedly not very common. Bingo seems better. Maybe it was too much? Does Sadie get milk thistle?
Sadie just jumped up – she’s VERY hungry and telling me – somehow I hit a key and lost all I had typed! Sadie – have you been conspiring with Bingo?!?!
What I think I said was:
Sadie had a problem with her BM’s at least one to one and a half months prior to starting the prednisone weaning. And going from 15mg from 40mg didn’t make a difference. That was why I stopped the prednisone weaning and started the Atopica weaning. After just two weeks, I saw a marked difference in her BM’s AND her attitude and overall disposition.
I have communicated with two cocker spaniel fur parents and both their AIHA dogs had facial paralysis (palsy), came on about three-four months into Atopica and it did not subside until off the Atopica. I have seen a bit of an improvement in Sadie’s palsy. But I don’t know if that is because of the holistic vet and the acupuncture/supplements (I’ve actually stopped all but two, they made her BM’s worse – gotta watch those supplements….).
About the milk thistle. It’s funny you mention this because I have been giving Sadie this for over a while and just last week I added a bit more. I usually give her 20 drops, AM and PM, in her food along with the SAM-e (10 drops), but for some reason, I put more. Not good – we’re back to the 20 drops and all is fine again. Maybe try less?
Poor Bingo. His poo is not good. Trust me, nothing worked to help Sadie with her loose poo (sorry to be talking about this – but it’s an AIHA thing too….). I tried pumpkin, a tad – a lot. I tried yogurt, a tad – a lot. I tried pro-biotics. Vet meds. Nothing worked. Lowering the Atopica – wella – seems to be better.
Okay – going to feed that ravenous little girl whom JUST had a hair cut and a bath. She’ll be ready for bed, clean and full tummy. :)
You know Linda, I’m scared of giving Bingo a bath. He hates them and gives me the “WHY – WHAT HAVE I DONE!!!!!” look and I’m scared I’ll kill him from the stress. Hence he gets out of it all the time. But he really needs one and today’s another scorcher. If tomorrow’s hot – that’s the day Bingo gets clean.
You know, I do remember Bingo’s poos seemed better after we reduced his atopica to every second day. Just lately again, they are mucking up, that’s what has me blaming the prednisone again, thinking the reduction has been noticed. Don’t apologise, we can talk about poos :) poo poo poo poo.
Please dreams.
Vally & Bingo
Not for the reason of GI trouble (more so her thinning skin and calcium deposits, enlarged liver and concern for wound healing if she she needed to have surgery) but our vet says it’s a priority to get Tilly off her pred ASAP. He doesn’t mind if she stays on cyclosporine and mycophenolate but definitely not pred longterm.
She relapsed last December after being off all meds for 7 weeks. We attempted a pred reduction this past March and her PCV fell so she remained at the full dose for 5 more months. Since August we’ve worked out a very slow which the vet is a little impatient about but I won’t have it any other way!
Just curious, how many times have your dogs’ relapsed? Does it get harder and harder to arrest the autoimmune process the more times they relapse?
Vally – funny gal. Bingo – how about a NICE warm bath today in the tub? Sadie loves that. Good boy.
Erica – Poor you and Tilly. I am so sorry about the relapse. It’s our worst fear (after the initial onset, of course).
Sadie has relapsed once before. At onset of AIHA, she responded VERY well to the pred and Atopica, fast. My vet was sort of feeling his way through this and at a weak moment (MINE) and against everything I was told on VetNet, I let him talk me into weaning Sadie fast. I think they now call it the ‘five day weaning plan’ and it should NOT BE DONE! Sadie, and others from what I understand, have not done well with it. It was a weaning that reduced all meds, normal dose; every other day for fives days, then every two days for five days, then every three days for fives days then, every five days for five days. Sadie’s PCV started to drop on the third day of the five of every three days. Not drastically, but by about three-five points (we were testing PCV every other day at this point….as I remember). Then on the fourth day of the fives days, she collapsed THREE times before I could get her to the vet.
When I rushed her in to the vet, I didn’t have to say anything – they knew – they were WRONG. We immediately tested her PCV – 20. Down from the 42 when we started weaning and one point lower than onset of AIHA on March 30th. I was in tears. We started her back at square one with full force of prednisone/Atopica, daily. Plus, and I had to remind them to give her a shot of prednisone to jump start her (da – look at her chart!) when her PCV did not climb right away. That did it – the shot, it started to climb again. That was the end of June. Her PCV rose a little slower this time, but we’re now back at 44 (as of last Saturday). We’re still weaning – BUT, very slow (again – thanks my dear friends here!!).
Listen to them HERE. And listen to your gut instinct. I knew to listen to all here and I was torn between my vet, that I knew wanted to do the right thing – but just lacked the experience – and the forum, that knew AND had experience. I’m not saying be confrontational with your vet – I’m just saying, tell them to listen to YOU. I actually printed pages from VetNet and took it in for them to read. I told them read it, these are fur parents that have been through it – for years – they know, they warned, I didn’t listen – now you, my wonderful vet, are going to listen to me AND them. SLOW, SLOW, SLOW weaning.
Now we are weaning at 25% (or about, not able to do with Atopica due to dosage/liquid capsules, so it ends up being 25% sometimes and then 33% sometimes….) for one month. This way there is time to adjust and hopefully, hopefully, the adrenal glands start to kick in and start working again, after being shut down for so long.
So far, so good with Sadie this time. Each pup is different. Sadie’s PCV was never that low. She was never in need of a transfusion. This is my experience – if I am saying anything wrong here, please correct me forum. Forum – nice to say that again.
You know – from the beginning my vet knew that the VetNet forum was right on target. I found the forum within a week (I was clued to the computer – researching – a deer in the headlights, I was). Immediately, I actually gave him the site of the forum and he was really impressed – we talked about it in length and he was glad that I was doing so much research and helping him understand this disease better AND how to treat it. He was very good in the hematology arena, so that helped immensely and how he caught the AIHA immediately at onset. I was lucky. I am not sure at what point he thought to wean fast. He was leaving the practice (he now does 90% rescue work) and had some health issues going on at that time. What I’m saying is – I truly believe the vets mean well, but with AIHA – listen to them here. I flub up all the time and they reel me back.
Good luck with Tilly. It’s all crushing and exhausting. Trying to stay just one step ahead of it all is a daily ordeal. Just remember – bottom line – SLOW WEANING. :)
Love and hugs to you and Tilly, Linda and Sadie
My lab mix has Immune Mediated Thrombocytopenia. She’s been on prednisone (started at 40 mg, went down to 20mg, now on 20mg every other day. She’s also on 300mg cyclosporine a day. We are ready to get her off all her meds. Unfortunatley for her, she would be on medication for a lifetime. She no longer has the quality of life she’s been used to. And, the cost is prohibitive after seven months on these medications.
I just don’t know how to wean her off the cyclosporine.