Information on Cyclosporine – to freeze or not to freeze?

[Vally]

Thank you Jeremy for this.

Regards, Vally

[Pamela]

Hi Jeremy,
Thank you for sharing your info but my concern, like Dorothy’s, is about the Atopica LIQUID freezing not the capsules. I will call both Elanco, the manufacturer and the vendor I bought the medication from but I am not sure I will receive a straight answer so I looking online.

[Jeff]

Freezing has no effect on pharmacokinetics absorption
https://www.ncbi.nlm.nih.gov/pubmed/26178603

[Patrice]

Admin note:
“ATOPICA should be stored and dispensed in the original unit-dose container at controlled room temperature between 59 and 77°F (15-25°C).”
See:
https://docs.google.com/viewerng/viewer?url=https://www.secondchanceaihadogs.com/wp-content/uploads/2015/04/atopica-product-insert.pdf

I asked Dr. Dodds who advised that I should check with the manufacturer who responded with the same information: stored between 59 and 77°F .

If dosing it is causing diarrhea, vomiting and other stomach upset then it can be given with food for a few days. Most dogs in the study (read the product insert) adjust to it after a short period of time.

I suspect freezing damages the preparation of the “microemulsion in an aqueous environment.” Specifically it is a cyclic polypeptide “metabolite by the fungal species Beauveria nivea” consisting of 11 amino acids.

[Frances DeBerry]

I left the cyclosporine out over night instead of freezing it or leaving in the frig. will this effect the medication

[Vally]

Hi Frances, we don’t recommend freezing Cyclosporine at all. Does your dog have trouble stomaching it? I know that’s why freezing is suggested. We recommend for intolerance to start with giving it with a small amount of food at t e beginning.

I know freezing has become popular, but Patrice, the site owner has checked with the manufacturers and they also suggest it be kept between 59 and 77°F.

I believe it is because the Company hasn’t tested the efficacy of the drug after freezing, whereas it has been tested at the temperatures they recommend.

I guess if it were me, and this is not a medical recommendation, I would leave that packet out of the freezer now and finish it, and keep future boxes at room temperature.

I hope your doggie is doing well.

Regards, Vally