Corticosteroid

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Corticosteroids (also called glucocorticoids /cortisone /steroids) are used for a wide variety of ailments due to their anti-inflammatory action & their ability to suppress auto-immune responses & allergic reactions. Continuous, high daily dosage for over week or so can stop the body making it’s own corticosteroids, so these medications must NEVER be stopped abruptly because of potentially fatal withdrawal side effects (Addisonian Crisis). High dose corticosteroids are an essential part of AIHA treatment, but will result in side effects in the long term (Cushing’s Disease).

Corticosteroids can be given orally, given by injection or topically (applied directly to the affected area for skin problems). In the treatment of AIHA, corticosteroids may initially be given by injection and orally thereafter.

Common Corticosteroids include: Prednisone, prednisolone, methylated prednisolone, dexamethasone, betamethasone, triamcinolone, hydrocortisone. In cases of AIHA, high dose prednisone is generally referred to as the cornerstone of treatment and is the drug of choice for this disease. In acute onset cases, injectable dexamethasone may be used in preference at the start of the treatment

Side effects include increased thirst, increased urination, increased appetite, panting (heavy breathing), loss of energy & weakness, muscular atrophy, worsening of infections, nausea & /or vomitting (rare), diabetes (usually reversible when corticosteroids are stopped), symptoms of iatrogenic Cushings Disease.

Please also see glossary term for prednisone for information.